Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip

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United States of America

PATENT NO 12241085
APP PUB NO 20210130774A1
SERIAL NO

17041672

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Abstract

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Described herein is a microphysiological system for models of disease. Specifically, induced pluripotent stem cells (iPSCs) and iPSC-derived cells, including those obtained from disease patients, are seeded onto microfluidic “chip” devices to study cellular development and disease pathogenesis. Herein, neurodegenerative disease modeling, including Parkinson's Disease (PD) is shown to reproduce key PD pathology in a vascularized human model that contains neurons relating to PD pathology. Such compositions and methods are used for research for PD biomarkers, patient screening for PD risk assessment, and therapeutic discovery and testing. A panel of biomarkers are generated through analysis of living PD-chips by neural activity, whole transcriptomic, proteomic, and metabolomic analysis, and functional enzyme tests of media and tissue. Introducing therapeutics through a vasculature channel, coupled with blood brain barrier penetration studies can be assessed for efficacy in the human neural cells present in the PD-Chip.

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Patent Owner(s)

  • CEDARS-SINAI MEDICAL CENTER

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Laperle, Alexander North Hollywood, US 8 38
Sances, Samuel Santa Monica, US 13 73
Svendsen, Clive N Pacific Palisades, US 10 95
Yucer, Nur Los Angeles, US 5 37

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