Multi-compartment device containing human three-dimensional (3D) microtissues for toxicity testing

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United States of America

PATENT NO 12241049
APP PUB NO 20220081659A1
SERIAL NO

17420107

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Abstract

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This dual-compartment liver co-culture system exposes target microtissue to metabolites, allowing for evaluating toxicity using a standard multi-well plate for high throughput analysis. Discovery scientists can rapidly select lead compounds with desirable metabolic profiles, while safety scientists can determine the safety of drugs, pesticides, and environmental chemicals. This platform is allometrically scalable, so it can mimic the natural size differences between healthy organs and, with the liver, produce sufficient quantities of metabolites. The device is simple to use and designed for immediate in vitro pathology assessment using confocal microscopy, transcriptomics, and proteomics.

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Patent Owner(s)

  • BROWN UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boekelheide, Kim East Greenwich, US 5 529
Hall, Susan Saunderstown, US 11 40
Ip, Blanche Providence, US 3 10
Li, Hui Cranston, US 1361 15841
Morgan, Jeffrey Sharon, US 8 93

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