Extracellular vesicles isolated from genetically modified cells over-expressing SERPINB3 for use in medicine

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United States of America

PATENT NO 12239667
APP PUB NO 20220143098A1
SERIAL NO

17430739

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Abstract

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The present invention concerns the therapeutic use of extracellular vesicles isolated from a genetically modified cell line over-expressing SerpinB3. In particular, said therapeutic use aimed at the treatment of acute pathologies characterized by ischemic or inflammatory tissue damage or by cell injury due to oxidative stress, such as cardiac, cerebral, intestinal, renal or limb ischaemia. Further examples of use consist of the preservation of transplant organs, including heart, lung, liver, bladder, pancreas and intestine. In a further aspect the invention relates to the use of a pharmaceutical composition comprising extracellular vesicles isolated from a genetically modified cell line over-expressing SerpinB3 and a pharmaceutically acceptable vehicle.

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Patent Owner(s)

  • UNIVERSITÀ DEGLI STUDI DI PADOVA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Biasiolo, Alessandra Selvazzano Dentro, IT 4 0
Muraca, Maurizio Padua, IT 6 11
Pontisso, Patrizia Padua, IT 4 0
Quarta, Santina Villaguattera di Rubano, IT 4 0
Ruvoletto, Mariagrazia Vigonovo, IT 4 0
Villano, Gianmarco Padua, IT 4 0

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