Suture-free coagulation-assisted fixed cardiac patch and preparation method thereof

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United States of America

PATENT NO 12239521
APP PUB NO 20240335272A1
SERIAL NO

18695835

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Abstract

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A suture-free coagulation-assisted fixed cardiac patch and fabrication method thereof are provided. The cardiac patch includes a polymeric procoagulant base and a barbed microneedle fixed on the polymeric procoagulant base, and a side surface of the polymeric procoagulant base with the microneedle has a microporous structure which does not penetrate the solid base of the polymer; an included angle α between the microneedle and the plane where the polymeric procoagulant base located is 60-90°, and the microneedles are evenly distributed on the polymeric procoagulant base at a density of 5-50 threads/cm2; the barbs are located on the curved surface of the microneedle and are inclined toward the polymeric procoagulant base. The fabrication method includes using a mold pore-forming, a porogen pore-forming, or a thermally induced phase separation pore-forming, and combining the barbed microneedle while forming the microporous structure to obtain a suture-free coagulation-assisted fixed cardiac patch.

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Patent Owner(s)

  • ZHEJIANG UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gao, Changyou Hangzhou, CN 9 43
Hong, Xiaoqian Hangzhou, CN 1 0
Lu, Yuwen Hangzhou, CN 2 0
Ren, Tanchen Hangzhou, CN 1 0
Shen, Liyin Hangzhou, CN 2 0
Zhu, Yang Hangzhou, CN 29 3293

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