Methods and compositions for preserving tissues and organs

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12239126
APP PUB NO 20200236924A1
SERIAL NO

16705966

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Abstract

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The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.

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Patent Owner(s)

  • THE GENERAL HOSPITAL CORPORATION

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berendsen, Timothy Antonie Melrose, US 3 8
Bieganski, Robert Marius Cambridge, US 3 8
Izamis, Maria-Louisa Boston, US 10 46
Perk, Sinem Chicago, US 3 8
Toner, Mehmet Wellesley, US 179 7163
Usta, Osman Berk Watertown, US 6 8
Uygun, Basak Elif Newton, US 3 8
Uygun, Mustafa Korkut Newton, US 14 35
Yarmush, Martin L Newton, US 55 613

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