Humanized IL-6 and IL-6 receptor

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United States of America

PATENT NO 12239111
APP PUB NO 20220053742A1
SERIAL NO

17385039

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Abstract

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Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.

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Patent Owner(s)

Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dore,, Jr Anthony T Tarrytown, US 9 153
Murphy, Andrew J Croton-on-Hudson, US 509 7038
Stevens, Sean Del Mar, US 219 3937
Wang, Li-Hsien Somers, US 27 373

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