Synthesis of beta-hydroxyisovalerate and methods of use

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United States of America

PATENT NO 12234495
APP PUB NO 20220325304A1
SERIAL NO

17658214

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Abstract

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The biological production of beta-hydroxyisovalerate (βHIV) using at least one non-natural enzyme. The non-natural enzyme for the biologically-derived βHIV provides more beta-hydroxyisovalerate synthase activity than the wild-type parent. The non-natural enzyme having one or more modifications of substrate-specificity positions. The non-natural enzyme can be expressed in a microorganism, such as a yeast or bacteria, wherein the microorganism comprises an active βHIV metabolic pathway for the production of βHIV. Alternatively, the non-natural enzyme can be a βHIV synthase used to produce βHIV in a cell-free environment. The biological derivation of βHIV eliminates toxic by-products and impurities that result from the chemical production of βHIV, such that βHIV produced by a non-natural enzyme prior to any isolation or purification process has not been in substantial contact with any halogen-containing component.

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Patent Owner(s)

  • SASYA INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cameron, Elizabeth A New Brighton, US 3 0
Lindsay, Christopher St. Paul, US 7 4
Roberg-Perez, Kevin Minneapolis, US 12 38
Snow, Christopher D St. Paul, US 5 4
Vemuri, Goutham Maple Grove, US 4 6

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