Modified compounds and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12234447
APP PUB NO 20230068063A1
SERIAL NO

17697577

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Abstract

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The present disclosure provides oligomeric compound comprising a modified oligonucleotide having a central region comprising one or more modifications. In certain embodiments, the present disclosure provides oligomeric compounds having an improved therapeutic index or an increased maximum tolerated dose.

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Patent Owner(s)

Patent OwnerAddress
IONIS PHARMACEUTICALS INCCALIFORNIA USA CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crooke, Stanley T Carlsbad, US 155 5482
Liang, Xue-Hai Del Mar, US 20 22
Migawa, Michael T Carlsbad, US 36 1004
Oestergaard, Michael Carlsbad, US 39 209
Seth, Punit P Carlsbad, US 183 5026
Shen, Wen Carlsbad, US 19 167
Swayze, Eric E Encinitas, US 355 10308

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