Efficient deposition of nano-sized particles onto cells at an air liquid interface

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12234440
APP PUB NO 20200407675A1
SERIAL NO

16912486

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Abstract

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An apparatus and method for the delivery and deposition of particles air-liquid-interface (ALI) cell cultures includes a sample inlet coupled to a growth tube having interior walls that are wet. The growth tube is configured to operate at a first temperature along a first length of the tube and a second temperature along a second length positioned between the first length and a growth tube outlet. The apparatus also includes a nozzle plate having a plurality of nozzles. The exposure chamber adapted to hold cell cultures at an air-liquid interface positioned underneath the plurality of nozzles and a temperature regulator adapted to control a temperature of the exposure chamber. The apparatus also includes a controller including instructions operable to cause the controller to maintain a relative humidity within the exposure chamber by controlling at least the second temperature of the growth tube and the temperature of the exposure chamber.

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Patent Owner(s)

  • AEROSOL DYNAMICS INC.; UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Eiguren, Fernandez Arantzazu Richmond, US 4 14
Lewis, Gregory Stephen Berkeley, US 14 40
Spielman, Steven Russel Oakland, US 19 54
Tilly, Trevor Benson Columbus, US 1 0
Wu, Chang-Yu Gainesville, US 51 410

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