Hydrophobic interaction chromatography for viral clearance

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United States of America

PATENT NO 12234277
APP PUB NO 20210221840A1
SERIAL NO

17150973

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Abstract

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The present application provides a method for characterizing and/or determining viral clearance capacity of hydrophobic interaction chromatography (HIC) including experimental design for multivariate analysis of viral clearance of HIC. The method provides understanding of the mechanism of the viral clearance using HIC by running a D-Optimal design of experiment including evaluations of multiple factors, such as pH, buffer concentration, column loading concentration, flow rate of column, or hydrophobic strength of the HIC column.

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Patent Owner(s)

  • REGENERON PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mattila, John Nyack, US 23 86
Ruppino, John Boonton, US 1 0
Stairs, Robert Wellborn, US 8 0

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