Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof
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United States of America
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Feb 25, 2025
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Mar 24, 2022
app pub date -
May 19, 2021
filing date -
May 19, 2021
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Abstract
The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant CoChop protein. Methods of the invention include administering a composition comprising a mutant CoChop to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels.
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