Dimethylacrylamide (DMAA) hydrogel for expansion microscopy (ExM)

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United States of America

PATENT NO 12233184
APP PUB NO 20210196856A1
SERIAL NO

17144551

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Abstract

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The invention provides a method for preparing an expanded cell or tissue sample suitable for microscopic analysis. Expanding the sample can be achieved by binding, e.g., anchoring, key biomolecules to a DMAA-TF polymer network and swelling, or expanding, the polymer network, thereby moving the biomolecules apart as further described herein. As the biomolecules are anchored to the polymer network isotropic expansion of the polymer network retains the spatial orientation of the biomolecules resulting in an expanded, or enlarged, sample.

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Patent Owner(s)

  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boyden, Edward Stuart Chestnut Hill, US 32 1101
Gao, Linyi Cambridge, US 41 552
Gao, Ruixuan Cambridge, US 12 100
Obidin, Nikita Somerville, US 5 6

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