Polynucleotides encoding antibodies which bind the EC3 domain of cadherin-6 (CDH6) and possess internalization ability

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United States of America

PATENT NO 12233155
APP PUB NO 20230226205A1
SERIAL NO

17874239

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Abstract

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It is an object of the present invention to provide an antibody binding to CDH6 and having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody, the antibody-drug conjugate or the pharmaceutical product, and the like. The present invention provides an anti-CDH6 antibody having internalization activity, an antibody-drug conjugate of the antibody and a drug having antitumor activity, a pharmaceutical product comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

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Patent Owner(s)

Patent OwnerAddress
DAIICHI SANKYO COMPANY LIMITED3-5-1 NIHONBASHI HONCHO CHUO-KU TOKYO 103-8426 JAPAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hirata, Tsuyoshi Tokyo, JP 54 970
Nakamura, Kensuke Tokyo, JP 65 483
Saito, Atsuko Tokyo, JP 8 30

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