Hyperbranched polyglycerol-coated particles and methods of making and using thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12233140
APP PUB NO 20240173216A1
SERIAL NO

18514738

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Abstract

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Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

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Patent Owner(s)

  • THE TRUSTEES OF YALE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Deng, Yang Edison, US 48 63
Ediriwickrema, Asiri Cary, US 9 11
Saltzman, W Mark New Haven, US 40 154

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