Method of endogenous stem cell activation for tendon/ligament osseointegration
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United States of America
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Feb 25, 2025
Grant Date -
Mar 21, 2019
app pub date -
Feb 28, 2017
filing date -
Feb 28, 2017
priority date (Note) -
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Abstract
Tendon and ligament injuries are common in orthopaedic clinical practice and cause substantial morbidity in sports and in routine daily activities. While surgical reconstruction is effective, the majority of patients suffer from a prolonged period of recovery because of limited regeneration capacity of the tendon-bone interface. Here, the Inventors have established an approach for promoting tendon/ligament integration. By first recruiting endogenous stem cells to the site of injury, bone morphogenic proteins (BMPs), are then delivered in vivo to promote repair. Significant acceleration of healing via the above methods and compositions leads to fast recovery and return to normal activities, thereby providing new therapeutic avenues for treatment of injuries involving the tendon-bone interface.
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