Adenoviral expression vector and methods and cell lines for production

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12227754
APP PUB NO 20210310025A1
SERIAL NO

17223785

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Abstract

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An adenovirus expression vector is provided. The adenovirus expression vector may include: a) one or more mutations that render the adenovirus replication incompetent and b) at least one nucleotide sequence encoding a protein or an RNA is provided. A method of synthesizing an adenovirus vector is also provided. The synthesis may include: a) producing a plurality of overlapping adenovirus sub-fragments, each sub-fragment comprising a portion of the full genome of the adenovirus; b) circularizing the sub-fragments to form plasmid structures; and c) assembling the circularized sub-fragments into a linear structure, wherein the vector comprises a combination of two or more sub-fragments. A mammalian cell line configured to replicate adenoviral vectors, wherein the cell line comprises nucleotide sequences expressing E1A and E1B gene products but is devoid of other adenovirus sequences is also provided.

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Patent Owner(s)

Patent OwnerAddress
LUNG BIOTECHNOLOGY PBC1000 SPRING STREET SILVER SPRING MARYLAND 20910 UNITED STATES OF AMERICA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Exline, Colin San Diego, US 6 0
Liu, Huizhu San Deigo, US 11 32
Stevens, Sean Del Mar, US 219 3937

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