Systems for cell culture scaling

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12227732
APP PUB NO 20230091993A1
SERIAL NO

18051126

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Abstract

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The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

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Patent Owner(s)

  • LIFE TECHNOLOGIES CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brau, Christopher Grand Island, US 7 82
Jones, Nephi Newton, US 7 7
Smith, Mark Nibley, US 353 5522

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