Modulation of intestinal epithelial cell differentiation, maintenance and/or function through T cell action

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12227578
APP PUB NO 20190263912A1
SERIAL NO

16348911

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Abstract

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An atlas of intestinal epithelial cells, intestinal epithelial stem cells and intestinal immune cells identifies new cell populations, markers, networks, and responses to stimuli. Intestinal T cells drive intestinal epithelial cell differentiation and activity. Accordingly, disclosed are methods of modulating intestinal epithelial cell differentiation, maintenance and/or function, related methods for the treatment of disease, including IBD. Also disclosed are methods and kits for identifying cell types, their differentiation, homeostasis and activation.

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Patent Owner(s)

  • THE BROAD INSTITUTE, INC.; MASSACHUSSETTS INSTITUTE OF TECHNOLOGY; THE GENERAL HOSPITAL CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Biton, Moshe Cambridge, US 4 10
Haber, Adam Cambridge, US 8 13
Herbst, Rebecca H Cambridge, US 3 9
Ordovas-Montanes, Jose Cambridge, US 6 10
Regev, Aviv Cambridge, US 146 1011
Rogel, Noga Cambridge, US 1 3
Rozenblatt-Rosen, Orit Cambridge, US 20 117
Shalek, Alexander K Cambridge, US 51 474
Shekhar, Karthik Cambridge, US 4 68
Smillie, Christopher Cambridge, US 3 7
Xavier, Ramnik Boston, US 29 77

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