Trispecific binding proteins, methods, and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12227573
APP PUB NO 20230220079A1
SERIAL NO

18183107

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Abstract

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Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

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Patent Owner(s)

Patent OwnerAddress
SANOFI54 RUE LA BOÉTIE PARIS 75008

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beil, Christian Frankfurt am Main, DE 29 255
Beninga, Jochen Frankfurt Am Main, DE 16 82
Birkenfeld, Joerg Frankfurt Am Main, DE 8 21
Cameron, Béatrice Paris, FR 24 124
Dabdoubi, Tarik Paris, FR 23 209
Lemoine, Cendrine Paris, FR 21 73
Nabel, Gary J Cambridge, US 131 4161
Prades, Catherine Paris, FR 21 109
Qiu, Huawei Westborough, US 70 353
Rao, Ercole Morfelden-Waldorf, DE 59 535
Regula, Joerg Munich, DE 10 117
Seung, Edward Cambridge, US 15 104
Wei, Ronnie Needman, US 29 216
Wu, Lan Cambridge, US 22 161
Xing, Zhen Cambridge, US 30 10
Xu, Ling Cambridge, US 114 594
Yang, Zhi-Yong Cambridge, US 61 517

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