Use of gene editing to generate universal TCR re-directed t cells for adoptive immunotherapy

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United States of America

PATENT NO 12227555
APP PUB NO 20210155667A1
SERIAL NO

17147521

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Abstract

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The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.

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Patent Owner(s)

  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liu, Xiaojun Wallingford, US 95 424
Pan, Wei Philadelphia, US 172 1920
Zhao, Yangbing Lumberton, US 58 796

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