Pharmaceutical compounds
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United States of America
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-
Feb 18, 2025
Grant Date -
Sep 29, 2022
app pub date -
Aug 20, 2020
filing date -
Aug 20, 2020
priority date (Note) -
In Force
status (Latency Note)
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Abstract
Benzodiazepine derivatives of formula (I): (I) wherein: each of R1 and R2 is independently H or halo; either (i) T is N, Z is C, and
are bonds, and
and
are absent; or (ii) T is C, Z is N,
and
are bonds, and
and
are absent; each of R3 and R4 is independently halo, —OR6, —NR6R7, —COR8, —C(O)OR8, —CON(R8)2 or —R6; R5 is H or halo; each of R6 and R7 is independently H or a group selected from C1-C6 alkyl, C3-C10 cycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; R8 is H or C1-C6 alkyl, each R8 being the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
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