Nano-satellite complexes

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12226491
APP PUB NO 20210346478A1
SERIAL NO

17232751

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Abstract

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The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles. In some embodiments, administration of the nanosatellite complexes to a subject with cancer achieves long-term cancer remission (e.g., when combined with an immune checkpoint inhibitor, such as αPD1).

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bugada, Luke Ann Arbor, US 1 0
Chen, Hongwei Ann Arbor, US 38 94
Clauson, Ryan Ann Arbor, US 1 0
Gao, Wei Ann Arbor, US 459 3897
Hill, Brett Ann Arbor, US 1 0
Li, Chengyi Ann Arbor, US 4 5
Rizvi, Syed Monem Ann Arbor, US 1 0
Sun, Duxin Ann Arbor, US 41 426
Wen, Fei Ann Arbor, US 14 32

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