Phosphor-containing drug activator, suspension thereof, system containing the suspension, and methods for use

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12226483
APP PUB NO 20220080045A1
SERIAL NO

17538770

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Abstract

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A method for treating a disease in a subject in need thereof is provided involving infusing 8-methoxypsoralen (8-MOP) and a phosphor-containing drug activator into a diseased site in the subject; and delivering a dose of x-rays to the subject for production of the ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose including a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor, wherein the phosphor-containing drug activator includes an admixture of two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays; the two or more phosphors including Zn2SiO4:Mn2+ and (3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+) at a ratio (Zn2SiO4:Mn2+):(3Ca3(PO4)2Ca(F, Cl)2:Sb3+, Mn2+)) of from 1:10 to 10:1; wherein each of the two or more phosphors have at least one coating selected from an ethyl cellulose coating or a diamond-like carbon coating.

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Patent Owner(s)

Patent OwnerAddress
IMMUNOLIGHT LLC1901 ST ANTOINE STREET 6TH FLOOR AT FORD FIELD DETROIT MICHIGAN 48226 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adamson, Justus Durham, US 17 74
Beyer, Wayne F Ivanhoe, US 19 243
Bourke,, Jr Frederic A Aspen, US 103 1450
Fathi, Zakaryae Raleigh, US 123 1909
Nolan, Michael Raleigh, US 120 2432
Oldham, Mark Durham, US 65 865
Walder, Harold Oak Island, US 76 1157

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