Substrates for covalent tethering of proteins to functional groups or solid surfaces

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United States of America

PATENT NO 12221648
APP PUB NO 20210340593A1
SERIAL NO

17374460

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Abstract

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The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.

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Patent Owner(s)

  • PROMEGA CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hitko, Carolyn W Grover Beach, US 12 54
Kirkland, Thomas Atascadero, US 73 336
Levin, Sergiy San Luis Obispo, US 12 28
Meisenheimer, Poncho San Luis Obispo, US 54 386
Ohana, Rachel Friedman Madison, US 28 106
Uyeda, Harry Tetsuo Los Osos, US 18 55
Zhu, Ji Croton on Hudson, US 54 663

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