Mutated immunoglobulin-binding polypeptides

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12221492
APP PUB NO 20210147577A1
SERIAL NO

17149830

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO 26 or SEQ ID NO 27, wherein at least the alanine residue at the position corresponding to position 42 in SEQ ID NO:4-7 has been mutated to arginine and/or wherein at least the aspartic acid residue at the position corresponding to position 37 in SEQ ID NO:4-7 has been mutated to glutamic acid.

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Patent Owner(s)

  • CYTIVA BIOPROCESS R&D AB

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ander, Mats Uppsala, SE 38 237
Bjorkman, Tomas Uppsala, SE 41 362
Rodrigo, Gustav Uppsala, SE 43 350

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