Use of upstream open reading frame 45aa-uORF nucleotide sequence of PTEN gene and polypeptide coded by 45aa-uORF

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PATENT NO 12220446
APP PUB NO 20200138915A1
SERIAL NO

16620154

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Provided are an upstream Open Reading Frame (uORF) of a Phosphatase and Tensin homolog (PTEN) gene and a protein coded by the uORF. A potential ORF of 138 bases (45aa-uORF) in the 5′UTR of the PTEN, coding an oligopeptide of 45 amino acids (named PTEN-45aa) plays an important role in the development and progression progress of tumors. Further provided are a new diagnostic and therapeutic method and a drug screening platform for PTEN expression regulation related diseases, in particular neuroglioma. Also provided is a polypeptide for treatment of PTEN expression regulation related diseases.

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  • THE FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Zhang, Nu Guangdong, CN 6 2

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