Inert matrices for qualitative and semi-quantitative seed amplification assays

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United States of America

PATENT NO 12220445
APP PUB NO 20230084155A1
SERIAL NO

17931104

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Inert matrices for use with α-synuclein seed amplification assays (αS-SAAs) are provided. The inert matrices accurately reflect the absence of misfolded αS protein when used as a negative control, in the form of no, perceptively low, or delayed αS substrate self-aggregation, yet will readily permit aggregation of the αS substrate with seeds when used as a positive control. The inert matrices may be used to screen for αS-SAA reagent competence. The inert matrices may be used to dilute samples taken from peripheral biological matrices. Finally, the inert matrices may be used as a diluent for serial dilutions of αS-SAA samples, to enable semi-quantitative versions of αS-SAAs.

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Patent OwnerAddress
AMPRION INC149 NEW MONTGOMERY STREET SAN FRANCISCO CA 94105

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Concha, Luis San Diego, US 11 4
Farris, Carly San Diego, US 8 4
Ma, Yihua Corona, US 34 4
Nguyen, Hieu Huu San Diego, US 1 0

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