Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies

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United States of America

PATENT NO 12214189
APP PUB NO 20210023362A1
SERIAL NO

16938778

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Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (<<1 s) technique which enables monitoring of inter-burst and intra-burst impedance during EBTs in real-time. FAST identified a frequency which delineates thermal effects from electroporation effects in measured impedance. Significance: FAST demonstrates the potential to perform EIS, in addition to intra-burst impedance spectroscopy, using existing pulse generator topologies.

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Patent Owner(s)

  • VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.; ANGIO DYNAMICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arena, Christopher B Burlington, US 20 2234
Bhonsle, Suyashree Menlo Park, US 2 29
Davalos, Rafael V Blacksburg, US 74 4928
Epshteyn, Lucy Blacksburg, US 2 65
Lorenzo, Melvin F Blacksburg, US 1 29
White, Natalie Christiansburg, US 5 62

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