Method of treating or ameliorating metabolic disorders using GLP-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (GIPR)

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United States of America

PATENT NO 12214051
APP PUB NO 20210154318A1
SERIAL NO

17151045

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Abstract

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Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.

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Patent Owner(s)

Patent OwnerAddress
AMGEN INCONE AMGEN CENTER DRIVE THOUSAND OAKS CA 91320-1799

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Yuan Newbury Park, US 119 2620
Falsey, James R Moorpark, US 16 157
Herberich, Bradley J Newbury Park, US 18 256
Holder, Jerry Ryan Simi Valley, US 14 55
Lu, Shu-Chen Thousand Oaks, US 13 36
Miranda, Leslie P Thousand Oaks, US 30 519
Netirojjanakul, Chawita Longmont, US 5 17
Sham, Kelvin Thousand Oaks, US 15 281
Stanislaus, Shanaka Thousand Oaks, US 7 42
Venient-Ellison, Murielle M Thousand Oaks, US 1 0
Wu, Bin Thousand Oaks, US 269 4282
Xu, Jing Waltham, US 575 4672
Yie, Junming Warren, US 12 168

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