Cell for use in enzyme assays
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United States of America
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Jan 28, 2025
Grant Date -
Apr 11, 2024
app pub date -
May 18, 2023
filing date -
May 18, 2023
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Abstract
Cells are described that are useful in rapid, sensitive, and accurate cell-based assays for enzyme activity, particularly for enzyme activities associated with botulinum toxins. Such cell expresses a construct that includes an anchor region, a cleavage site, and a reporting region having two or more identical reporter peptides. Enzymatic activity at the cleavage site releases the reporter region into the cytosol of the cell, where multiple degradation events occur. The observed change in the signal is proportional to the enzymatic activity.
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