Anti-CD45 antibodies and conjugates thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12209135
APP PUB NO 20240254251A1
SERIAL NO

18598342

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Abstract

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Disclosed are anti-CD45 antibodies, antigen binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45. Such antibodies and ADCs are useful in therapeutic methods, including methods of depleting CD45+ cells from a patient. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy, and to improve the engraftment of hematopoietic stem cell transplants, by selectively depleting endogenous CD45+ cells prior to the transplant procedure.

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Patent Owner(s)

Patent OwnerAddress
VOR BIOPHARMA INC100 CAMBRIDGE PARK DR SUITE 400 CAMBRIDGE MA 02140

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boitano, Anthony Newton, US 50 72
Cooke, Michael Boston, US 59 261
Cruite, Patricia Ann Medford, US 4 1
McDonagh, Charlotte Fenton Winchester, US 11 30
Palchaudhuri, Rahul Somerville, US 36 102
Panwar, Rajiv Acton, US 15 27
Pearse, Bradley R Watertown, US 18 41
Widboom, Paul Fredrick Hanover, US 13 15

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