ADAM6 mice

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12207628
APP PUB NO 20210105984A1
SERIAL NO

17129706

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

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Patent Owner(s)

  • REGENERON PHARMACEUTICALS, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Karow, Margaret Santa Rosa Valley, US 94 1357
Macdonald, Lynn Harrison, US 279 3552
Murphy, Andrew J Croton-on-Hudson, US 509 7038
Stevens, Sean Del Mar, US 219 3937

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