Multivariate spectral analysis and monitoring for biomanufacturing

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United States of America Patent

PATENT NO 12205680
APP PUB NO 20190272894A1
SERIAL NO

16290713

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Abstract

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The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

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Patent Owner(s)

Patent OwnerAddress
GENZYME CORPORATION500 KENDALL STREET CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barrett, Shawn L Bridgewater, US 3 7
Hincapie, Marina Bridgewater, US 7 25
Kang, Xuezhen Bridgewater, US 3 7
Pollock, Julie Susanne Bridgewater, US 2 7
Tewari, Jagdish C Bridgewater, US 2 7
Wasalathanthri, Dhanuka Pulasthi Fiskdale, US 2 7

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