Oral health model for high throughput screen and characterization of oral hygiene products

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United States of America Patent

PATENT NO 12203926
APP PUB NO 20220091101A1
SERIAL NO

17309896

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Abstract

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An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.

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Patent Owner(s)

Patent OwnerAddress
COLGATE-PALMOLIVE COMPANY300 PARK AVENUE NEW YORK NY 10022 UNITED STATES OF AMERICA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Daep, Carlo Brooklyn, US 24 27
Masters, James Ringoes, US 68 434
Trivedi, Harsh Mahendra Hillsborough, US 44 71
Yang, Ying Monmouth Junction, US 168 1582
Zenobia, Camille Hampton, US 5 13

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