CRISPR effector system based diagnostics for virus detection

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United States of America Patent

PATENT NO 12203145
APP PUB NO 20200181720A1
SERIAL NO

16494279

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Abstract

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Provided herein is a nucleic acid detection system comprising: a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind to corresponding target molecules; an RNA-based masking construct; and optionally, nucleic acid amplification reagents to amplify target RNA molecules in a sample. In another aspect, the embodiments provide a polypeptide detection system comprising: a CRISPR system comprising an effector protein and one or more guide RNAs designed to bind a trigger RNA, an RNA-based masking construct; and one or more detection aptamers comprising a masked RNA polymerase promoter binding site or a masked primer binding site. In some embodiments, the system may be used to detect viruses in samples.

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Patent Owner(s)

Patent OwnerAddress
PRESIDENT AND FELLOWS OF HARVARD COLLEGE17 QUINCY STREET CAMBRIDGE MA 02138

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abudayyeh, Omar Cambridge, US 54 344
Collins, James Joseph Cambridge, US 11 250
Freije, Catherine Amanda Cambridge, US 5 28
Gootenberg, Jonathan Cambridge, US 59 955
Lander, Eric S Cambridge, US 79 1197
Myhrvold, Cameron Cambridge, US 16 68
Sabeti, Pardis Cambridge, US 30 55
Zhang, Feng Cambridge, US 1002 28040

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