Method to identify subjects at higher risk to develop an autoimmune disease based on genetic and/or phenotypic screening for epistatic variants in DDX39B (RS2523506) and IL7R (RS6897932)

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United States of America Patent

PATENT NO 12203138
APP PUB NO 20210180133A1
SERIAL NO

17182846

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Abstract

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The present invention includes a method, kits, and assays for identifying a human subject as having an increased risk of developing an autoimmune disease, or a human subject with multiple sclerosis caused by elevated soluble Interleukin 7 receptor (sIL7R), by obtaining a biological sample and detecting or measuring in the biological sample an amount of a soluble Interleukin-7 receptor (sIL7R) and an amount of an RNA Helicase DDX39B, whereby a lower expression of DDX39B and a higher secretion of sIL7R identifies the subject from which the biological sample was obtained as having an increased risk of developing an autoimmune disease, when compared to a human subject not having an autoimmune disease. The present invention also includes a method of modifying a treating of subjects based on the lower expression of RNA Helicase DDX39B alone or in combination with an increase in sIL7R.

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Patent Owner(s)

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DUKE UNIVERSITY2812 ERWIN ROAD SUITE 406 DURHAM NC 27705

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barcellos, Lisa F El Cerrito, US 2 3
Bradrick, Shelton S Galveston, US 7 5
Briggs, Farren B S Cleveland Heights, US 2 3
Evsyukova, Irina Cedar Grove, US 2 3
Galarza-Munoz, Gaddiel Galveston, US 6 5
Garcia-Blanco, Mariano A Galveston, US 34 252
Gregory, Simon G Durham, US 8 22
Ko, Dennis C Durham, US 2 3

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