System and method for clarifying a cell culture harvest solution
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United States of America Patent
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Jan 21, 2025
Grant Date -
Jun 24, 2021
app pub date -
May 13, 2019
filing date -
May 11, 2018
priority date (Note) -
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Abstract
A system for clarifying a cell culture harvest solution, including target molecules and dynamic filter media. A filtration vessel includes a flexible liner and at least one filter having a surface on which the dynamic filter media accumulates into a cake. The cake and filter during filtration operation permit a filtrate including target molecules to pass therethrough while preventing unwanted solid materials from passing therethrough. A backflush source includes a backflush fluid and is fluidly connected to the filtration vessel via the at least one filter. The backflush source, during backflush operation, is adapted to supply backflush fluid back through the at least one filter for removing the cake formed on the filter. Related systems and methods are also disclosed.
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