Norcoclaurine synthases with increased activity

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United States of America Patent

PATENT NO 12203118
APP PUB NO 20230193333A1
SERIAL NO

16623053

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Abstract

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The invention relates to norcoclaurine synthases and substrate binding sites having one or more site-specific mutation which increase the activity, when compared to the wild type synthase, of the condensation of 4-HPAA and dopamine to (S)-norcoclaurine and/or 3,4-DhPAA and dopamine to (S)-norlaudanosoline. The inventors both identified specific mutations corresponding to at position 73, 75, 77, 82, 99, 114, 141, 142, 147, 152, 174 and/or 178 in the count according to SEQ ID No: 1, and sites corresponding to the binding domains defined in SEQ ID NO: 4 and 5, where the mutated increase of the activity may be positioned within these norcoclaurine synthases. These domains are conserved regions.

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Patent Owner(s)

  • RIVER STONE BIOTECH, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berninger, Philipp Friedrich Reinach, CH 5 0
Grassinger, Franziska Reinach, CH 3 0
Hatsch, Anaelle Reinach, CH 4 5
Heal, Jon Richard Reinach, CH 3 0
Houghton-Larsen, Jens Copenhagen, DK 28 296
Occhipinti, Laura Reinach, CH 6 5
Schwab, Markus Reinach, CH 50 431
Sheridan, Joseph Michael Reinach, CH 7 16

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