Universal platform for genetic code expansion

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United States of America Patent

PATENT NO 12203115
APP PUB NO 20210002626A1
SERIAL NO

16934484

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Abstract

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Methods and compositions are described for selecting and identifying orthogonal aminoacyl synthetase-tRNA pairs and their use to incorporate unnatural amino acids in a site-specific manner in proteins. Specifically described is a novel E. coli tyrptophanyl synthetase-tRNA pair that functions as both an opal and amber suppressor and that incorporates tryptophan analogs into proteins.

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Patent Owner(s)

  • TRUSTEES OF BOSTON COLLEGE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chatterjee, Abhishek Brookline, US 14 26
Italia, James Brighton, US 3 1

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