Fusion proteins for improved precision in base editing

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United States of America Patent

PATENT NO 12203077
APP PUB NO 20200354729A1
SERIAL NO

16640337

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Abstract

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Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.

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Patent Owner(s)

Patent OwnerAddress
SHANGHAITECH UNIVERSITYROOM 207 ADMINISTRATION CENTER NO 393 MIDDLE HUAXIA ROAD PUDONG NEW AREA SHANGHAI 201210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Jia Shanghai, CN 193 1777
Huang, Xingxu Shanghai, CN 10 0
Li, Xiaosa Shanghai, CN 2 0
Liu, Yajing Shanghai, CN 18 36
Wang, Ying Shanghai, CN 968 7243
Yang, Bei Shanghai, CN 14 65
Yang, Li Shanghai, CN 438 2742

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