Nucleic acids encoding switch receptors using IL-9 receptor signaling domains
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United States of America Patent
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Jan 21, 2025
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Aug 24, 2023
app pub date -
Sep 16, 2022
filing date -
Sep 17, 2021
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Abstract
The present disclosure generally relates to, inter alia, a class of chimeric switch receptors containing an endodomain of an IL-9 receptor, engineered to modulate transcriptional regulation in a ligand-dependent manner. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating gene expression, modulating an activity of a cell, and/or for the treatment of various health conditions or diseases.
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