Selective androgen receptor degrader (SARD) ligands and methods of use thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 12202815
APP PUB NO 20210340122A1
SERIAL NO

17273726

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

This invention is directed to selective androgen receptor degrader (SARD) compounds including heterocyclic rings and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedys disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION400 W SUMMIT HILL DRIVE - UT TOWER 961A KNOXVILLE TN 37902

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
He, Yali Germantown, US 44 1310
Hwang, Dong-Jin Arlington, US 30 254
Miller, Duane D Collierville, US 179 4313
Narayanan, Ramesh Tuscaloosa, US 56 684
Ponnusamy, Thamarai Daejeon, KR 34 267

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Jul 21, 2028
7.5 Year Payment $3600.00 $1800.00 $900.00 Jul 21, 2032
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jul 21, 2036
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00