Method for 3D-micro-patterning
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United States of America Patent
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Jan 21, 2025
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app pub date -
Apr 21, 2021
filing date -
Mar 17, 2020
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Abstract
Recently, we have introduced 3D-micro-patterned pharmaceutical dosage forms for enhancing the efficacy, safety, convenience, and cost-effectiveness of drug therapies. Presented herein are an apparatus and a method for the manufacture of such dosage forms. The apparatus comprises at least a first extruder and at least a second extruder. The first extruder comprises an extruder channel having an exit port with a valve mated to an input port of a second extruder. Said second extruder comprises a translatable piston for extruding plasticized fiber at controlled speed. The apparatus further comprises a stage movable at the controlled speed of the extruded fiber for depositing said fiber to a three dimensional structural framework. The method includes extruding plasticized matrix from a first extruder into a second extruder, extruding said plasticized matrix from the second extruder through a fiber fabrication exit port at controlled speed to form extruded fiber, and depositing said extruded fiber onto a fiber assembling stage to form a three dimensional structural framework.
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