Compositions for modulating an XBP1 pathway in a keratinocyte and methods of use

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United States of America Patent

PATENT NO 12201687
APP PUB NO 20220218821A1
SERIAL NO

17558977

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Abstract

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Provided herein are compositions and methods for increasing an immune response in a subject, immunizing a subject and/or treating a disease in a subject that relate to keratinocytes. It is a surprising finding of the present invention that modulation of an XBP1 pathway creates a keratinocyte that is itself an immune modulator, or adjuvant. In some embodiments, the concentration of antigen is increased in the vicinity of the keratinocyte, further increasing the immune response by effector cells within that vicinity.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION1ST FLOOR GARDNER STEEL CONFERENCE CENTER 130 THACKERAY AVENUE PITTSBURGH PA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Falo,, Jr Louis D Wexford, US 24 267
You, Zhaoyang Pittsburgh, US 8 124

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