Intracellular delivery of biomolecules to induce tolerance

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United States of America Patent

PATENT NO 12201652
APP PUB NO 20190111082A1
SERIAL NO

16098404

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Abstract

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The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.

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Patent Owner(s)

Patent OwnerAddress
STEMCELL TECHNOLOGIES CANADA INCVANCOUVER BRITISH COLUMBIA V6A 1B6

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bernstein, Howard Cambridge, US 141 6810
Gilbert, Jonathan B Somerville, US 13 164
Loughhead, Scott Watertown, US 11 33
Moore, Finola Watertown, US 4 20
Sharei, Armon R Watertown, US 32 396
Wang, Bu Watertown, US 16 93

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