Non-human animals comprising a humanized coagulation factor 12 locus

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 12201096
APP PUB NO 20240016129A1
SERIAL NO

18347009

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized coagulation factor XII (F12) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized F12 locus express a human coagulation factor XII protein or a chimeric coagulation factor XII protein, fragments of which are from human coagulation factor XII. Methods are provided for using such non-human animals comprising a humanized F12 locus to assess in vivo efficacy of human-coagulation-factor-XII-targeting reagents such as nuclease agents designed to target human F12. A short isoform of F12 that is produced locally in the brain, and methods of using the short isoform, are also provide.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591-6707

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alessandri-Haber, Nicole Rye Brook, US 6 40
Chalothorn, Dan New York, US 9 35
Macdonald, Lynn Harrison, US 279 3552
Mitnaul, Lyndon Piscataway, US 5 4
Morton, Lori Chappaqua, US 14 36
Tang, Yajun White Plains, US 18 37
Zamolodchikov, Daria Hastings-on-Hudson, US 3 4

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Jul 21, 2028
7.5 Year Payment $3600.00 $1800.00 $900.00 Jul 21, 2032
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jul 21, 2036
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00