High-throughput screening methods to identify small molecule targets

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United States of America

PATENT NO 12195730
APP PUB NO 20230109268A1
SERIAL NO

17899860

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Abstract

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Provided herein are methods for identifying pairs of protein binding partners, mutations of which may inform the discovery of pharmaceutically useful small molecules. The methods disclosed herein may allow for the adaptation of the native protein degradation system to modulate specific disease targets at the protein level, in particular, for targets that have long been considered undruggable.

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Patent Owner(s)

Patent OwnerAddress
A-ALPHA BIO INC4000 MASON ROAD FLUKE HALL SUITE 304 SEATTLE WA 98195

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Emerson, Ryan Seattle, US 10 83
Lopez, Randolph Seattle, US 10 12
Sen, Arpita Seattle, US 3 7
Younger, David Seattle, US 14 38

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