Linked perfusion to continuous-flow stirred-tank reactor cell culture system

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United States of America

PATENT NO 12195712
APP PUB NO 20210317395A1
SERIAL NO

17355325

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Abstract

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Methods of protein production in a linked culture and production bioreactor system are provided. Such methods include a culture bioreactor (N−1 bioreactor) linked to production bioreactor (N bioreactor). More specifically, the methods include (a) culturing cells with a gene that encodes the protein of interest in a continuous perfusion culture bioreactor (N−1 bioreactor); inoculating a continuously stirred tank reactor (CSTR) production bioreactor (N bioreactor) with cells obtained from step (a); and culturing the cells in the CSTR production bioreactor under conditions that allow production of the protein of interest.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER INGELHEIM INTERNATIONAL GMBH55216 INGELHEIM AM RHEIN

International Classification(s)

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  • 2021 Application Filing Year
  • H04M Class
  • 2693 Applications Filed
  • 1633 Patents Issued To-Date
  • 60.64 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coffman, Jonathan Gaithersbury, US 18 37
Gagnon, Matthew Paul Medford, US 6 1
Hiller, Gregory Walter Wakefield, US 17 116

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges1781101 - 1001002003004005006007008009001000110012001300140015001600170018001900

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