Formation of arrays of planar intestinal crypts possessing a stem/proliferative cell compartment and differentiated cell zone

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United States of America

PATENT NO 12195706
APP PUB NO 20240010960A1
SERIAL NO

18371636

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Abstract

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A method for producing tissue constructs comprising two or more distinct regions, each of which comprises a different cell population or lineage is described. The method involves providing a support substrate or substrate assembly comprising two or more physically distinct regions, wherein the two or more physically distinct regions of the support substrate or substrate assembly are different from each other; and depositing/positioning one or more cells on the support substrate or substrate assembly. The cells can form a continuous monolayer with at least two zones, e.g., a proliferative zone and a nonproliferative zone, that can act as in vitro intestinal models. The models are two-dimensional, thus facilitating rapid and facile imaging. Systems comprising the tissue constructs and methods of using the constructs to study the effects of pharmaceuticals, nutraceuticals, and metabolites on intestinal cells are also described.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL136 EAST ROSEMARY STREET SUITE 100 CHAPEL HILL NC 27514

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allbritton, Nancy L Seattle, US 18 129
Kim, Raehyun Chapel Hill, US 4 3
Wang, Yuli Lynnwood, US 53 688

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