Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with Fc-engineering

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United States of America

PATENT NO 12195555
APP PUB NO 20240034816A1
SERIAL NO

18469947

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Abstract

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The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-γ receptor.

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SANOFI54 RUE LA BOETIE PARIS 75008 FRANCE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beninga, Jochen Frankfurt am Main, DE 16 82
Chiron, Marielle Paris, FR 6 11
Focken, Ingo Frankfurt am Main, DE 12 49
Gauthier, Laurent Marseilles, FR 93 598
Gourdin, Nicolas Marseilles, FR 10 36
Masiero, Alessandro Paris, FR 4 1
Rao, Sambasiva Cambridge, US 6 22
Sevigny, Leila Cambridge, US 8 22
Tang, Alexandre Paris, FR 1 0
Virone-Oddos, Angela Paris, FR 10 3
Zhou, Yanfeng Cambridge, US 16 24

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